DNA Pharma® ESTROX Key Compounds :
Green Tea Extract:
Green Tea Extract is an herbal derivative from green tea leaves, containing antioxidant ingredients and caffeine.
This extract contains high amounts of catechins, including EGCG which helps with the metabolism of fat at rest and during exercise performance.
Green tea also reduces the formation of free radicals in the body which protect cells and molecules from damage.
Also functions to increase insulin sensitivity, promoting increases in muscle mass versus fat mass.
A meta-analysis of 11 studies looking at green tea consumption over a period of 12 weeks minimum noted, on average, 1.31kg weight loss.
DIM is a molecule that consists of two indole groups attached to a methane group. It is commonly found in broccoli and hold promise as an aromatase inhibitor.
DIM has potent effects on estrogen metabolism and is able to keep the body relatively balanced by preventing either drastic increases or decreases in estrogen.
DIM can both inhibit the aromatase enzyme (and prevent conversion of testosterone into estrogen) and it can act on more potent forms of estrogen and convert them into less potent forms; this conversion reduces the overall effects of estrogen in the body.
Glucaric acid, supplemented via its calcium salt (Calcium-D-Glucarate), is thought to be a chemoprotective and anti-toxin compound
Calcium D-Glucarate reduces total estrogen present in the body.
It has been found to repress the effects of beta-glucuronidases, which slows your body’s ability to eliminate harmful hormones and chemicals.
By doing this, Calcium D Glucarate speeds up the body’s ability to help excrete and eliminate dietary and environmental wastes.
Phosphatidylserine is a phospholipid found in cell membranes and is most concentrated in the brain where it comprises 15% of the total phospholipid pool.
PS can lower circulating cortisol.
PS is involved in governing membrane fluidity and therefore in the regulation of biological cell activities.
PS also modulates the activity of receptors, enzymes, ion channels and signaling molecules.
Research has shown PS can improve mood, cognitive function, performance, endocrine response to stress, and decrease soreness following exercise.
Q: What is the best way to take Estrox?
A: As a dietary supplement take 1 Serving (2 Capsules) in the morning. For optimal results, take for 4 weeks, then take 4 weeks off.
Q: What is a aromatase inhibitor and why is it important?
A: Aromatase is the enzyme responsible for converting testosterone to estrogen. Inhibition of the aromatase enzyme helps reduce the amount of testosterone that gets converted to estrogen. Certain ingredients found in Estrox Revolution act as aromatase inhibitors.
Q: What are the negative side effects of high cortisol levels in the blood?
A: High cortisol levels can decrease immunity, increase abdominal fat deposits, break down muscle, bone, and connective tissue and inhibit thyroid hormone activation. This is why it is important to keep cortisol levels in check.
1. Effects of ingestion of a commercially available thermogenic dietary supplement on resting energy expenditure, mood state and cardiovascular measures. Outlaw J, Wilborn C, Smith A, Urbina S, Hayward S. J Int Soc Sports Nutr. 2013 Apr 30;10(1):25.
2. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M, Chantre P, Vandermander J. Am J Clin Nutr. 1999 Dec;70(6):1040-5
3. Neurochemical and behavioral effects of green tea (Camellia sinensis): a model study. Mirza B, Ikram H, Bilgrami S, Haleem DJ, Haleem MA. Pak J Pharm Sci. 2013 May;26(3):511-6.
4. The effect of green tea extract on fat oxidation at rest and during exercise: evidence of efficacy and proposed mechanisms. Hodgson AB, Randell RK, Jeukendrup AE. Adv Nutr. 2013 Mar 1;4(2):129-40.
5. Metabolic response to green tea extract during rest and moderate-intensity exercise. Hodgson AB, Randell RK, Boon N, Garczarek U, Mela DJ, Jeukendrup AE, Jacobs DM. J Nutr Biochem. 2013 Jan;24(1):325-34.
1. Lo, R., & Matthews, J. (2010). A New Class of Estrogen Receptor Beta–Selective Activators. Molecular interventions, 10(3), 133.
2. Leong, H., Riby, J. E., Firestone, G. L., & Bjeldanes, L. F. (2004). Potent ligand-independent estrogen receptor activation by 3, 3′-diindolylmethane is mediated by cross talk between the protein kinase A and mitogen-activated protein kinase signaling pathways. Molecular Endocrinology, 18(2), 291-302.
3. Leong, H., Firestone, G. L., & Bjeldanes, L. F. (2001). Cytostatic effects of 3, 3′-diindolylmethane in human endometrial cancer cells result from an estrogen receptor-mediated increase in transforming growth factor-α expression. Carcinogenesis, 22(11), 1809-1817.
4. Sanderson, J. T., Slobbe, L., Lansbergen, G. W., Safe, S., & Van den Berg, M. (2001). 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells. Toxicological sciences, 61(1), 40-48.
5. Safe, S., Wang, F., Porter, W., Duan, R., & McDougal, A. (1998). Ah receptor agonists as endocrine disruptors: antiestrogenic activity and mechanisms. Toxicology letters, 102, 343-347.
1. Lonky, S. A. Calcium D-Glucarate.
2. Marsh, C. A. (1986). Biosynthesis of d-glucaric acid in mammals: a free-radical mechanism?. Carbohydrate research, 153(1), 119-131.
3. Dwivedi, C., Heck, W. J., Downie, A. A., Larroya, S., & Webb, T. E. (1990). Effect of calcium glucarate on β-glucuronidase activity and glucarate content of certain vegetables and fruits. Biochemical medicine and metabolic biology, 43(2), 83-92.
4. Zheng, Z., Fang, J. L., & Lazarus, P. (2002). Glucuronidation: an important mechanism for detoxification of benzo [a] pyrene metabolites in aerodigestive tract tissues. Drug metabolism and disposition, 30(4), 397-403.
1. Kingsley, M. I., Miller, M., Kilduff, L. P., McENENY, J. A. N. E., & Benton, D. (2006). Effects of phosphatidylserine on exercise capacity during cycling in active males. Medicine and science in sports and exercise, 38(1), 64-71.
2. Starks, M. A., Starks, S. L., Kingsley, M., Purpura, M., & Jäger, R. (2008). The effects of phosphatidylserine on endocrine response to moderate intensity exercise. Journal of the International Society of Sports Nutrition,5(1), 1-6.
3. Carter, J., & Greenwood, M. (2015). Phosphatidylserine for the Athlete.Strength & Conditioning Journal, 37(1), 61-68.
4. Kingsley, M. (2006). Effects of phosphatidylserine supplementation on exercising humans. Sports medicine, 36(8), 657-669.