GLYCOSLINTM the most powerful insulin driver and nutrient delivery enhancer on the market. Nutrient partitioning is the concept that the body can be activated to deliver nutrients, such as carbohydrates and protein, to the tissues we want (muscles) and not to the tissues we don’t want (adipose tissue or fat). This can be accomplished by activating insulin, the hormone that activates transporters of carbohydrate and protein, on muscle cells but not on fat. Compounds such as cyanidin-3-glucoside, banaba extract and berberine have demonstrated nutrient partitioning in studies, where muscle cells pull in the nutrients from high calorie diets while fat cells remain unaltered, or even shrink!
- Cyanidin-3-Glucoside – An extract form berries that, when combined with high calories, increases nutrient transport into the muscles while leaving fat tissue unaffected
- Berberine – This compound increases insulin sensitivity, so that insulin can do its job better and drive more carbs and protein into the muscle
- Banaba extract – An insulin mimetic, this leaf-derived extract acts like insulin and works synergistically with insulin in the body to dramatically increase nutrient delivery
- Cinnamon – This common spice has a dual action of acting as an insulin mimetic while also increasing insulin action
- Thioctic acid – Thioctic acid increases blood flow, so that more nutrients are able to be delivered to the musculature
Ingredient Profile :
Chromium is a trace mineral that needs to be consumed in small amounts for optimal functioning. One of its purposes is to modulate blood glucose by activating insulin action.
• Abdollahi et al. conducted a meta-analysis that demonstrated a reduction of blood glucose after supplementation with chromium, which means more glucose delivery to target tissues, such as muscle
• Chromium administration improved insulin sensitivity in a study by Kim et al., demonstrating that chromium can improve the effectiveness and action of insulin
• Anderson et al. showed that chromium can improve both carbohydrate and fatty acid delivery into target tissues
GENTIANA LUTEA 10:1 EXTRACT
Gentian root (Gentiana lutea) is a strongly bitter compound that has been used in traditional folk medicine for improving digestion.
• Rau et al. showed the beneficial effects that gentian has on peroxisome proliferator-activated receptors (PPAR) which control both lipid and glucose transport and delivery
• Gentian can increase digestive enzymes in the gastrointestinal tract, which will lead to more breakdown of food and better absorption of nutrients
Berberine is a powerful activator of glucose repartitioning and is as effective as many pharmaceuticals that are used for diabetics.
• Yan et al. showed that berberine can significantly improve insulin sensitivity and lower blood lipids more effectively than pioglitazone (a PPAR activator), indicating powerful nutrient repartitioning
• A meta-analysis illustrated that berberine exerts significant effects on carbohydrate and fat transport and delivery
• Other studies by Zhang et al. and Perez-Rubio et al. supported the above findings regarding berberine’s substantial effects on insulin and glucose
Also known as alpha-lipoic acid, thioctic acid can benefit by both increasing blood flow and nutrient repartitioning. As blood flow increases and more nutrients are delivered, thioctic acid will also keep the body in an anabolic state by downregulating AMP kinase, a “starvation” enzyme.
• Multiple studies demonstrated that thioctic acid improved blood flow, thereby increasing nutrient delivery
• Kim et al. (2004) reported that thioctic acid reduced AMP kinase, a sensor of low nutrient availability. Therefore, thioctic acid can increase nutrient delivery and storage by reducing AMP kinase.
• Other studies showed that thioctic acid can lower blood glucose and therefore improve carbohydrate delivery
A powerful addition to this formula, cinnamon can benefit nutrient delivery in many ways. Cinnamon can improve the effectiveness of endogenous insulin, while also acting as an insulin mimetic to supercharge the carbohydrate delivery to muscles.
• A hydroxychalcone derived from cinnamon is shown to act as an insulin mimetic in multiple studies
• A study by Broadhurst et al. showed that cinnamon can improve insulin function by 20-fold in vitro.
• The improvements on insulin action mentioned above are supported by reductions in blood glucose in multiple studies
Amylase is the enzyme that breaks down larger carbohydrates, such as starches, into smaller units during digestion for absorption into the body. This amylase, derived from a Japanese fungus used to ferment foods, ensures that carbohydrates in the diet will be fully absorbed for optimal carbohydrate uptake into the musculature.
• When eating large amounts of macronutrients, such as carbohydrates and proteins, all the nutrients may not be absorbed, and will instead be broken down and consumed by intestinal bacteria. Enzyme supplementation can reverse this trend.
• In a study by Quinten et al., an enzyme supplement improved digestion better than a commonly used medication
C3G – CYANIDIN-3-GLUCOSIDE
C3G is a bioactive substance from dark berries that exerts profound nutrient partitioning effects. C3G has been shown to increase carbohydrate uptake and to enhance insulin sensitivity through multiple mechanisms.
• Tsuda et al. showed that C3G combined with high calories aided in proper nutrient delivery to the muscles while keep fat tissue, blood glucose, and blood lipids unaffected
• Scazzocchio et al. demonstrated that C3G activates GLUT4 translocation, which means that more glucose transporters were available for increased carbohydrate delivery
• Another study supported the glucose transporter findings by showing that blood glucose and insulin sensitivity were enhanced with C3G supplementation
Banaba extract is another exciting botanical that has powerful nutrient repartitioning abilities, such that carbohydrate uptake is vastly improved while fat cells shrink simultaneously.
• Judy et al. demonstrated that Banaba extract for two weeks dropped blood glucose by 30%
• An ellagitannin from Banaba leaf induced insulin-like actions by a mechanism different from insulin, which would lead to synergistic benefits
• Liu et al. showed that a component of Banaba leaf can increase carbohydrate uptake via translocation of the GLUT4 receptor while inhibiting growth of fat cells
Vanadyl sulfate is a source of vanadium, an ultra-trace mineral that is essential, but in very small amounts.
• Similar to berberine, vanadium is able to inhibit certain signaling molecules such that the insulin receptor can act longer, thereby enhancing the effects of insulin.
• Cusi et al. showed that vanadyl sulfate improves insulin sensitivity and decreased blood glucose by 20%.
• Cohen et al. also found that insulin sensitivity is improved with vanadyl sulfate supplementation
Bioperine is a patented black pepper extract. Traditionally used for gastrointestinal disorders, it can benefit insulin action by both increasing intestinal absorption of carbohydrate and improving bioavailability of insulin activators, such as berberine and cinnamon.
• Bioperine has demonstrated increases of bioavailability of bioactive compounds of up to 2000%
• Bioperine downregulates enzymes that eliminate bioactive compounds from the body, such that their bioavailability is enhanced
• Bioperine increases absorption by decreasing intestinal motility rate, thereby allowing nutrients more time to be absorbed