NITRIC CORE EXTREME PUMP AND VASODILATION BY VITACORE

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  • Muscle Engorging Pumps*
  • Improves Exercise Performance*
  • Enhances Blood Flow*
  • Nitric Oxide Enhancer*
  • Non-Stimulatory*
  • Supports muscle strength, power, and endurance*
  • 50 servings per container
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Product Description

Nitric Core 6™ is a no-nonsense 6-in-1 extreme nitric oxide boosting formula containing innovative ingredients that work in synergy to create maximal blood vessel dilation, insane muscle hardness, and extreme pumps.  What’s more, triggering muscle growth during training is all about engorging the muscle with blood. The more nitric oxide you can produce, the more blood will flood into the muscle. The research backed and efficaciously dosed ingredients in Nitric Core 6™ are formulated specifically to help boost these levels to their peak and help you get more pump out of every rep! Nitric Core 6™ will give you explosive gains in muscle size, hardness, strength, and endurance. It’s the ultimate formulation for amplifying nitric oxide levels and creating an anabolic environment for muscle growth.

Key Ingredients/Benefits:

  • 750mg Nitrosigine– The world’s most effective form of arginine works synergistically with citrulline to maintain improved blood flow up to 3 hours.
  • 750mg Citrulline Malate– A dual-threat: Provides huge boosts to training volume and stimulates nitric oxide production. More training volume. Bigger pumps. Maximized gains.
  • 250mg Glycerol– Enhances plasma and intramuscular volume expansion, producing a more engorged muscular appearance.
  • 100mg Agmatine Sulfate– Induces vasodilation allowing more blood to reach working muscles.

Ingredient Profile:

Nitrosigine (Arginine Inositol Silicate):

Arginine (NITROSIGINE) is a precursor to nitric oxide and expands blood vessels to optimize blood flow. Silicate is contained within the walls of the arteries to help maintain their structural integrity.

• These ingredients work in synergy to help increase the blood flow and the structural integrity of the artery walls.
• Preclinical data has shown that Nitrosigine is superior to standard arginine… with 2x the blood flow in vasodilatation response.

Citrulline Malate:

Citrulline Malate is a non-essential amino acid that eventually converts to nitric oxide. Nitric oxide is a vasodilator that can help to lower blood pressure and improve blood flow to both organs and muscles.

• Studies have shown that Citrulline Malate enhances exercise tolerance by reducing levels of blood ammonia and lactate that are typically elevated during strenuous exercise.
• This ingredient will allow you to train with less rest in between sets and elevate your endurance capacity.
• A recent research study found individuals who consumed citrulline malate for 15 days were able to increase ATP production during exercise by 34% and improve phospho-creatine resynthesis after exercise by 20%.

Carnosyn Beta Alanine®:

Beta Alanine is an amino acid that is used to enhance muscular endurance. Reports of increased rep range are common. Also, the benefit is highly noticeable in moderate to high intensity cardio.

• Beta-Alanine’s effectiveness comes through boosting the synthesis of carnosine. Carnosine acts as an intra muscular buffer to keep the pH from dipping too low during a workout. To keep muscular strength through a workout, you need to have your pH levels optimal. If they drop too low, you have significantly less strength and fatigue quicker.
• Beta-Alinine synthesizes to carnosine which helps keep your pH levels in check by absorbing positive hydrogen molecules (H+) that are produced during periods of heavy exercise. By absorbing the H+ produced by strenuous exercise, your muscular pH levels are kept at an optimal level which will allow you to train harder and longer!
• A recent meta-analysis confirmed the ergogenic effect of beta-alanine, showing a 2.85% increase in exercise performance compared to placebo when dosed at ~2/grams daily.

Glycerol:

Glycerol (1,2,3-propanetriol) is a colorless, odorless, sweet tasting sugar alcohol. When consumed glycerol is rapidly absorbed primarily in the small intestine, distributed equally among all fluid compartments, and promotes hyperhydration by inducing an osmotic gradient.

• This brings potential benefits for endurance and stamina events, including adaptation to environmental heat/humidity stress, along with promoting blood flow associated with resistance training.
• Glycerol has also been shown to help athletes store extra water, delaying the need for hydration. This suggests improved efficiency in exercise, thermoregulation and decreased physiological stress.
• In addition, glycerol enhances plasma and intramuscular volume expansion, producing a more engorged muscular appearance.

Agmapure (Agmatine Sulfate):

Agmatine Sulfate helps improve nutrient partitioning which leads to an increase in muscle glycogen (carbs stored in muscle tissues) which then leads to more water retained WITHIN the muscle. This creates a fuller look to the muscles and a greater pump while hitting the iron.

• Agmatine Sulfate also increases NO production by working as a competitive inhibitor of the enzyme NO Synthase.
• There are studies to suggest that the nutrient partitioning effects of agmatine sulfate are possibly due to its ability to increase the insulin response to carbohydrates. This could be further explained by the increased blood flow to the muscle that occurs with increased NO production.
• LH and GH levels have been shown to be increased through the effects of Agmatine Sulfate and its possible effects on the hypothalamus.
• Agmatine has also been shown to manipulate pain receptors which may allow you to train past normal pain thresholds.

Beta Vulgaris:

Beta Vulgaris, also known as the common beet, has been shown to significantly reduce blood pressure. With this ingredient in Rhino Black, you can get a pump while lowering your blood pressure!

• Beet has also been shown to lower the oxygen cost of exercise and improve exercise tolerance.
• Lansley et al. (2011) found beet supplementation resulted an in mean power increase of 5%. Other studies have also shown supplementation with beet can improve time trial performance by 3-15%.

ELECTROLYTE BLEND

Potassium:

Potassium is a mineral found in varying amounts in almost all foods.

• It is needed for building and keeping strong bones.
• It also helps control the amount of calcium in the body and urine.
• If potassium levels get too high or too low, the heart and nervous system completely shut down. Many people in the U.S. often fail to obtain optimal amounts of this nutrient, and pay a health cost for it.

Calcium:

Calcium is an electrolyte that is necessary for many functions, especially muscle contraction.

• Therefore, the level of calcium in the blood has to be kept in a narrow range at all times.
• If the blood calcium level drops, then the bones will release calcium until an optimal level is once again achieved. However, this compromises the strength of the bones.
• Importantly, calcium is lost in sweat, so prolonged exercise requires calcium replenishment.

Magnesium:

Magnesium is an essential mineral and electrolyte. It is involved in protein synthesis, ATP formation, metabolism of carbohydrates and fats, and bone strength.

• Magnesium deficiencies are the second most common deficiency in developed countries. A lack of magnesium will raise blood pressure and reduce insulin sensitivity.
• Increases in free and total testosterone have been noted in sedentary and athletic populations when supplementing with magnesium supplementation. It also acts as a muscle relaxer and may improve aerobic performance.
• Brilla et al. (1992) discovered 26 untrained subjects who participated in a 7 week strength training program in conjunction with magnesium supplementation were able to increase testosterone relative to baseline.

Q: What is the best way to take Nitric Core 6?
A: As a dietary supplement take one serving 1 to 2 times daily.

Q: When should I take Nitric Core 6?
A: For optimal results take 15 minutes prior to working out.

Q: What exactly is “the pump” and does it do anything besides making your muscles look bigger?
A: From a scientific perspective the “pump”, commonly referred to as hyperemia, supplies working muscles with oxygen rich blood and nutrients while also removing waste products such as carbon dioxide. The more oxygenated blood and nutrients the muscles get the longer sustained contractions can take place…which ultimately leads to a pump and greater muscular growth. In fact, the cellular swelling that occurs with the pump may increase protein synthesis while also decreasing protein breakdown within the cell. This creates an optimal environment for muscle growth.

Q: What is vasodilation?
A: Vasodilation means enlargement of the blood vessels/veins. From a physiological perspective vasodilation provides more oxygen and nutrient blood to the working muscles which in turn may improve performance and cause a greater “pump”.

References : 

Nitrosigine:
1. Kalman, D. S., Feldman, S., Samson, A., & Krieger, D. R. (2015). A clinical evaluation to determine the safety, pharmacokinetics, and pharmacodynamics of an inositol-stabilized arginine silicate dietary supplement in healthy adult males. Clinical pharmacology: advances and applications, 7, 103.

Citrulline Malate:
1. Bendahan, D., Mattei, J. P., Ghattas, B., Confort-Gouny, S., Le Guern, M. E., & Cozzone, P. J. (2002). Citrulline/malate promotes aerobic energy production in human exercising muscle. British journal of sports medicine,36(4), 282-289.
2. Hickner, R. C., Tanner, C. J., Evans, C. A., Clark, P. D., Haddock, A., Fortune, C., … & Mccammon, M. (2006). L-citrulline reduces time to exhaustion and insulin response to a graded exercise test. Medicine and science in sports and exercise, 38(4), 660-666.
3. Pérez-Guisado, J., & Jakeman, P. M. (2010). Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. The Journal of Strength & Conditioning Research, 24(5), 1215-1222.
4. Sureda, A., Córdova, A., Ferrer, M. D., Pérez, G., Tur, J. A., & Pons, A. (2010). L-citrulline-malate influence over branched chain amino acid utilization during exercise. European journal of applied physiology, 110(2), 341-351.

Carnosyn Beta-Alanine:
1. Hobson, R. M., Saunders, B., Ball, G., Harris, R. C., & Sale, C. (2012). Effects of β-alanine supplementation on exercise performance: a meta-analysis. Amino acids, 43(1), 25-37.
2. Stout, J. R., Cramer, J. T., Zoeller, R. F., Torok, D., Costa, P., Hoffman, J. R., … & O’kroy, J. (2007). Effects of β-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women. Amino acids,32(3), 381-386.
3. Smith, A. E., Walter, A. A., Graef, J. L., Kendall, K. L., Moon, J. R., Lockwood, C. M., … & Stout, J. R. (2009). Effects of β-alanine supplementation and high-intensity interval training on endurance performance and body composition in men; a double-blind trial. Journal of the International Society of Sports Nutrition, 6(1), 1-9.
4. Baguet, A., Bourgois, J., Vanhee, L., Achten, E., & Derave, W. (2010). Important role of muscle carnosine in rowing performance. Journal of Applied Physiology, 109(4), 1096-1101.
5. Trexler, E. T., Smith-Ryan, A. E., Stout, J. R., Hoffman, J. R., Wilborn, C. D., Sale, C., … & Campbell, B. (2015). International society of sports nutrition position stand: Beta-Alanine. Journal of the International Society of Sports Nutrition, 12(1), 1-14.

Glycerol:
1. Bartos, J. (2013). A uniquely optimized, highly concentrated powdered form of glycerol delivering next-level hydration and next-gen product potential http://astromicnutrition.com/HydroMax_WhitePaper.pdf
2. Riedesel, M. L., Allen, D. Y., Peake, G. T., & Al-Qattan, K. (1987). Hyperhydration with glycerol solutions. Journal of Applied Physiology, 63(6), 2262-2268.
3. Lyons, T. P., Riedesel, M. L., Meuli, L. E., & Chick, T. W. (1990). Effects of glycerol-induced hyperhydration prior to exercise in the heat on sweating and core temperature. Medicine and Science in Sports and Exercise, 22(4), 477-483.
4. Goulet, E. D., Robergs, R. A., Labrecque, S., Royer, D., & Dionne, I. J. (2006). Effect of glycerol-induced hyperhydration on thermoregulatory and cardiovascular functions and endurance performance during prolonged cycling in a 25 C environment. Applied Physiology, Nutrition, and Metabolism, 31(2), 101-109.
5. Montner, P., Stark, D. M., Riedesel, M. L., Murata, G., Robergs, R., Timms, M., & Chick, T. W. (1996). Pre-exercise glycerol hydration improves cycling endurance time. International journal of sports medicine, 17(1), 27-33.

Agmatine Sulfate:
1. Ahn, S. K., S. Hong, et al. (2011). “Effects of agmatine on hypoxic microglia and activity of nitric oxide synthase.” Brain Res 1373: 48-54.
2. Arndt, M. A., V. Battaglia, et al. (2009). “The arginine metabolite agmatine protects mitochondrial function and confers resistance to cellular apoptosis.” Am J Physiol Cell Physiol 296(6): C1411-1419.
3. Berkels, R., D. Taubert, et al. (2004). “Agmatine signaling: odds and threads.” Cardiovasc Drug Rev 22(1): 7-16.
4. Gao, Y., B. Gumusel, et al. (1995). “Agmatine: a novel endogenous vasodilator substance.” Life Sci 57(8): PL83-86.
5. Haenisch, B., I. von Kugelgen, et al. (2008). “Regulatory mechanisms underlying agmatine homeostasis in humans.” Am J Physiol Gastrointest Liver Physiol 295(5): G1104-1110.
6. Halaris, A. and J. Plietz (2007). “Agmatine: metabolic pathway and spectrum of activity in brain.” CNS Drugs 21(11): 885-900.
7. L-arginine stimulation of glucose-induced insulin secretion through membrane depolarization and independent of nitric oxide.
8. Keynan, O., Mirovsky, Y., Dekel, S., Gilad, V. H., & Gilad, G. M. (2010). Safety and Efficacy of Dietary Agmatine Sulfate in Lumbar Disc‐associated Radiculopathy. An Open‐label, Dose‐escalating Study Followed by a Randomized, Double‐blind, Placebo‐controlled Trial. Pain Medicine, 11(3), 356-368.

Beta-Vulgaris
1. Lansley, K. E., Winyard, P. G., Fulford, J., Vanhatalo, A., Bailey, S. J., Blackwell, J. R., … & Jones, A. M. (2011). Dietary nitrate supplementation reduces the O2 cost of walking and running: a placebo-controlled study.Journal of Applied Physiology, 110(3), 591-600.
2. Cermak, N. M., Gibala, M. J., & Van Loon, L. J. (2012). Nitrate supplementation’s improvement of 10-km time-trial performance in trained cyclists. International Journal of Sport Nutrition andExercise Metabolism,22(1), 64.

Potassium:
1. Kanbay, M., Bayram, Y., Solak, Y., & Sanders, P. W. (2013). Dietary potassium: A key mediator of the cardiovascular response to dietary sodium chloride. Journal of the American Society of Hypertension, 7(5), 395-400.
2. Zhou, X., Zhang, Z., Shin, M. K., Horwitz, S. B., Levorse, J. M., Zhu, L., … & Pan, Y. (2013). Heterozygous disruption of renal outer medullary potassium channel in rats is associated with reduced blood pressure. Hypertension, 62(2), 288-294.

Calcium:
1. Barry et al. 2011; Acute Calcium Ingestion Attenuates Exercise-induced Disruption of Calcium Homeostasis
2. Paschoal et al. 2004; Nutritional status of Brazilian elite swimmers.
3. Venderley et al. 2006; Vegetarian diets : nutritional considerations for athletes.
4. Maughan et al. 2007; Nutrition and hydration concerns of the female football player.
5. Clarkson et al. 1995; Exercise and mineral status of athletes: calcium, magnesium, phosphorus, and iron.
6. Cinar et al. 2008; Testosterone levels in athletes at rest and exhaustion: effects of calcium supplementation.

Magnesium:
1. Cinar, V., Polat, Y., Baltaci, A. K., & Mogulkoc, R. (2011). Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion. Biological trace element research, 140(1), 18-23.
2. van der Plas, A. A., Schilder, J. C., Marinus, J., & van Hilten, J. J. (2013). An explanatory study evaluating the muscle relaxant effects of intramuscular magnesium sulphate for dystonia in complex regional pain syndrome. The Journal of Pain, 14(11), 1341-1348.
3. Hatzistavri, L. S., Sarafidis, P. A., Georgianos, P. I., Tziolas, I. M., Aroditis, C. P., Zebekakis, P. E., … & Lasaridis, A. N. (2009). Oral magnesium supplementation reduces ambulatory blood pressure in patients with mild hypertension. American journal of hypertension, 22(10), 1070-1075.
4. Golf, S. W., Bender, S., & Grüttner, J. (1998). On the significance of magnesium in extreme physical stress. Cardiovascular Drugs and Therapy,12(2), 197-202.
5. Carpenter, T. O., DeLucia, M. C., Zhang, J. H., Bejnerowicz, G., Tartamella, L., Dziura, J., … & Cohen, D. (2006). A randomized controlled study of effects of dietary magnesium oxide supplementation on bone mineral content in healthy girls. The Journal of Clinical Endocrinology & Metabolism, 91(12), 4866-4872.
6. Held, K., Antonijevic, I. A., Künzel, H., Uhr, M., Wetter, T. C., Golly, I. C., … & Murck, H. (2002). Oral Mg (2+) supplementation reverses age-related neuroendocrine and sleep EEG changes in humans. Pharmacopsychiatry,35(4), 135-143.
7. Brilla, L. R., & Haley, T. F. (1992). Effect of magnesium supplementation on strength training in humans. Journal of the American College of Nutrition,11(3), 326-329.

Nutritional Info

NITRICCORE

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200 Capsules

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